作者: Natalya Kurochkina , Udayan Guha , Zhong Lu
DOI: 10.1007/978-3-319-20098-9_7
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摘要: Expression and increased activity of receptor nonreceptor tyrosine kinases is a characteristic many cancers. Receptor kinase epidermal growth factor (EGFR) one the key molecules associated with cancer. Mutant alleles EGFR L858R Del E746-A750, which are common in human lung adenocarcinomas, result phosphorylation signaling molecules. inhibitor MIG6 more phosphorylated bronchial epithelial cells expressing mutant compared to those wild type EGFR. Activation results from formation homodimer or heterodimer. its active form resembles inactive conformations Src Hck. In this chapter, oncogenic drug-resistant forms described together various modes interactions substrates inhibitors.