Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1

摘要: The dynamic nature of cancer stem cells that underlie metastasis or their ability to switch between different cellular identities, as in EMT and MET, has profound implications for therapy. functional relationship molecules involved cell stemness is not clear. In this regard, our studies on hGBM tissue grade IV specimens showed significant expression Twist1 Sox2, known mesenchymal related markers, respectively, indicating association with glial tumor genesis metastasis. glioma obtained from CD133+ demonstrated increased Sox2 accompanied by increase the markers such N-cadherin, vimentin β-catenin. Our treatment human umbilical cord blood derived- cells, down regulation proteins, apart other markers. Based vitro experiments vivo intracranial xenograft mouse model studies, we elucidated potential therapeutic role hUCBSC suppressing induction MET.