Epithelial to Mesenchymal Transition and Progression of Glioblastoma

摘要: Glioblastoma multiforme (GBM) is the most common primary brain tumor among adults. Rapid progression and diffuse invasion of tissue restrict therapeutic options result in poor prognosis despite advances understanding this tumor’s molecular biology pathophysiology [1-4]. Current standard therapy consists a combination resection, irradiation temozolomide. Advances field have led to development targeted therapy, epidermal growth factor receptor (EGFR) has been introduced as one potential target [5]. Although pre-clinical studies shown promising effects, clinical applications yielded no significant benefit comparison with therapy. This fact encouraged extensive investigations studying mechanisms underlying GBM resistance EGFR-targeted Epithelial mesenchymal transition (EMT) considered an important contributing towards by diminishing [1-6].