The estimated incidence of gastrointestinal stromal tumors in France. Results of PROGIST study conducted among pathologists.
作者： Geneviève Monges , Ségolène Bisot-Locard , Jean-Yves Blay , Anne-Marie Bouvier , Marisol Urbieta
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摘要: Abstract The aim of this study was to investigate the incidence gastrointestinal stromal tumors (GISTs) in France. Method This prospective epidemiological performed among pathologists who were asked report exhaustively cases GIST over a one-year period. Results Five hundred ninety-one GISTs reported, 535 new and 56 relapse. So, estimated France 8.5–10 per million inhabitants 2005. main characteristics as follows: mean age 65 (± 13.2) years; 48.6% men; circumstances discovery: fortuitous 30.5%, symptomatic 46.5%, unknown 23%. primary tumor locations stomach 63.7%, small intestine 21.5%, mesentery 6.5%, colon rectum 3.2%, esophagus 0.7%, 4.3% listed unknown. Globally, 95.3% cKIT (CD117) positive. Based on size mitotic rate, 490 localized GISTs, 14.7% considered have very low prognostic risk, 25.5% 23.1% intermediate high risk. Conclusions provides for first time an estimation France, results are comparable what has been reported studies other European countries.
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