Cellular Plasticity in Cancer
作者： Salina Yuan , Robert J. Norgard , Ben Z. Stanger
DOI: 10.1158/2159-8290.CD-19-0015
关键词:
摘要: During cancer progression, tumor cells undergo molecular and phenotypic changes collectively referred to as cellular plasticity. Such result from microenvironmental cues, stochastic genetic epigenetic alterations, and/or treatment-imposed selective pressures, thereby contributing heterogeneity therapy resistance. Epithelial-mesenchymal plasticity is the best-known case of cell plasticity, but recent work has uncovered other examples, often with functional consequences. In this review, we explore nature role(s) these diverse programs in premalignant evolution, adaptation consider ways which targeting could lead novel anticancer treatments. SIGNIFICANCE: Changes identity, or are common at different stages it become clear that can be a potent mediator progression chemoresistance. Understanding mechanisms underlying various forms may deliver new strategies for most lethal aspects cancer: metastasis resistance therapy.
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sci-hub.se 参考文章(116)
Michael W. Klymkowsky, Pierre Savagner, Epithelial-Mesenchymal Transition The American Journal of Pathology. ,vol. 174, pp. 1588- 1593 ,(2009) , 10.2353/AJPATH.2009.080545
Manuel Amieva, Richard M. Peek, Pathobiology of Helicobacter pylori-induced Gastric Cancer Gastroenterology. ,vol. 150, pp. 64- 78 ,(2016) , 10.1053/J.GASTRO.2015.09.004
Jian Xu, Samy Lamouille, Rik Derynck, TGF-beta-induced epithelial to mesenchymal transition. Cell Research. ,vol. 19, pp. 156- 172 ,(2009) , 10.1038/CR.2009.5
Xin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton, Robert A. Weinberg, Distinct emt programs control normal mammary stem cells and tumour-initiating cells Nature. ,vol. 525, pp. 256- 260 ,(2015) , 10.1038/NATURE14897
Dany Nassar, Cédric Blanpain, Cancer Stem Cells: Basic Concepts and Therapeutic Implications Annual Review of Pathology-mechanisms of Disease. ,vol. 11, pp. 47- 76 ,(2016) , 10.1146/ANNUREV-PATHOL-012615-044438
Samy Lamouille, Jian Xu, Rik Derynck, Molecular mechanisms of epithelial–mesenchymal transition Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 178- 196 ,(2014) , 10.1038/NRM3758
Branden D. Tarlow, Carl Pelz, Willscott E. Naugler, Leslie Wakefield, Elizabeth M. Wilson, Milton J. Finegold, Markus Grompe, Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes Cell Stem Cell. ,vol. 15, pp. 605- 618 ,(2014) , 10.1016/J.STEM.2014.09.008
Pelayo Correa, Blanca M Piazuelo, Keith T Wilson, Pathology of Gastric Intestinal Metaplasia: Clinical Implications The American Journal of Gastroenterology. ,vol. 105, pp. 493- 498 ,(2010) , 10.1038/AJG.2009.728
L. V. Sequist, B. A. Waltman, D. Dias-Santagata, S. Digumarthy, A. B. Turke, P. Fidias, K. Bergethon, A. T. Shaw, S. Gettinger, A. K. Cosper, S. Akhavanfard, R. S. Heist, J. Temel, J. G. Christensen, J. C. Wain, T. J. Lynch, K. Vernovsky, E. J. Mark, M. Lanuti, A. J. Iafrate, M. Mino-Kenudson, J. A. Engelman, Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002003
Zhenfeng Zhang, Jae Cheol Lee, Luping Lin, Victor Olivas, Valerie Au, Thomas LaFramboise, Mohamed Abdel-Rahman, Xiaoqi Wang, Alan D Levine, Jin Kyung Rho, Yun Jung Choi, Chang-Min Choi, Sang-We Kim, Se Jin Jang, Young Soo Park, Woo Sung Kim, Dae Ho Lee, Jung-Shin Lee, Vincent A Miller, Maria Arcila, Marc Ladanyi, Philicia Moonsamy, Charles Sawyers, Titus J Boggon, Patrick C Ma, Carlota Costa, Miquel Taron, Rafael Rosell, Balazs Halmos, Trever G Bivona, Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer Nature Genetics. ,vol. 44, pp. 852- 860 ,(2012) , 10.1038/NG.2330