Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Seiji Yano,, Emiko Nakataki, Shinsaku Ohtsuka, Mami Inayama, Hideki Tomimoto, Nobutaka Edakuni, Soji Kakiuchi, Naoki Nishikubo, Hiroaki Muguruma, Saburo Sone, Retreatment of lung adenocarcinoma patients with gefitinib who had experienced favorable results from their initial treatment with this selective epidermal growth factor receptor inhibitor: a report of three cases. Oncology Research. ,vol. 15, pp. 107- 111 ,(2005) , 10.3727/096504005775082020

John D. Minna, Adi Gazdar, Joyce E. Ohm, Denise Juroske, Jonathan R. Pollack, Michael Peyton, Kiyoshi Yanagisawa, Yuhui Huang, Joseph Amann, J. Stuart Salmon, Hisayuki Shigematsu, David P. Carbone, Pierre P. Massion, Shailaja Kalyankrishna, Young H. Kim, Jonathan M. Kurie, Luc Girard, Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Research. ,vol. 65, pp. 226- 235 ,(2005)

W. Wang, Q. Li, T. Yamada, K. Matsumoto, I. Matsumoto, M. Oda, G. Watanabe, Y. Kayano, Y. Nishioka, S. Sone, S. Yano, Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clinical Cancer Research. ,vol. 15, pp. 6630- 6638 ,(2009) , 10.1158/1078-0432.CCR-09-1001

Akihiro Yoshimoto, Kanako Inuzuka, Toshiyuki Kita, Atsuhiro Kawashima, Kazuo Kasahara, Remarkable effect of gefitinib retreatment in a patient with nonsmall cell lung cancer who had a complete response to initial gefitinib. The American Journal of the Medical Sciences. ,vol. 333, pp. 221- 225 ,(2007) , 10.1097/MAJ.0B013E31803B8ACB

Takayuki Kosaka, Yasushi Yatabe, Hideki Endoh, Kimihide Yoshida, Toyoaki Hida, Masahiro Tsuboi, Hirohito Tada, Hiroyuki Kuwano, Tetsuya Mitsudomi, Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib Clinical Cancer Research. ,vol. 12, pp. 5764- 5769 ,(2006) , 10.1158/1078-0432.CCR-06-0714

Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia Sequist, Neal I. Lindeman, Carly Murphy, Sara Akhavanfard, Beow Y. Yeap, Yun Xiao, Marzia Capelletti, A. John Iafrate, Charles Lee, James G. Christensen, Jeffrey A. Engelman, Pasi A. Jänne, Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Cancer Cell. ,vol. 17, pp. 77- 88 ,(2010) , 10.1016/J.CCR.2009.11.022

Hirotoshi Dosaka-Akita, Philip T. Cagle, Hiromitsu Hiroumi, Masahiro Fujita, Motoyuki Yamashita, Anupama Sharma, Yoshikazu Kawakami, William F. Benedict, Differential retinoblastoma and p16INK4A protein expression in neuroendocrine tumors of the lung Cancer. ,vol. 88, pp. 550- 556 ,(2000) , 10.1002/(SICI)1097-0142(20000201)88:3<550::AID-CNCR9>3.0.CO;2-D

S. M. Rothenberg, J. A. Engelman, S. Le, D. J. Riese, D. A. Haber, J. Settleman, Modeling oncogene addiction using RNA interference Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 12480- 12484 ,(2008) , 10.1073/PNAS.0803217105

Maureen F Zakowski, Marc Ladanyi, Mark G Kris, None, EGFR mutations in small-cell lung cancers in patients who have never smoked The New England Journal of Medicine. ,vol. 355, pp. 213- 215 ,(2006) , 10.1056/NEJMC053610

Juping Yuan, J�rgen Knorr, Michael Altmannsberger, Gerd Goeckenjan, Andr� Ahr, Anton Scharl, Klaus Strebhardt, Expression of p16 and lack of pRB in primary small cell lung cancer. The Journal of Pathology. ,vol. 189, pp. 358- 362 ,(1999) , 10.1002/(SICI)1096-9896(199911)189:3<358::AID-PATH452>3.0.CO;2-1