作者: Ru Zhang , Lingli Tu , Lan Sun
DOI: 10.3978/J.ISSN.2072-1439.2014.04.36
关键词:
摘要: Tyrosine kinase inhibitors (TKIs) are highly effective agents for the treatment of lung cancer which harbors activated gene mutation. However, patients with failure TKI, TKI re-treatment beyond progression (TRBP) is still a potential option that has been proven by many literatures. In this review, we summarize clinical evidence TRBP and discuss mechanisms to overcome TKI-acquired resistance.