Expression of p16 and lack of pRB in primary small cell lung cancer.
作者： Juping Yuan , J�rgen Knorr , Michael Altmannsberger , Gerd Goeckenjan , Andr� Ahr
DOI: 10.1002/(SICI)1096-9896(199911)189:3<358::AID-PATH452>3.0.CO;2-1
关键词:
摘要: The retinoblastoma protein (pRB), p16, and cyclin D1 are major components of the RB pathway, which controls G1 checkpoint cell cycle. Proper regulation this pathway is crucial for normal proliferation. Abnormal forms these proteins have been found in various types malignant tumours. In present report, immunohistochemical techniques were applied to study expression pRB, 161 samples primary small lung cancer (SCLC) 20 non-small (NSCLC). While pRB staining was negative specimens SCLC, p16 observed 153 samples. contrast 16 out NSCLC cases exhibited 15 showed expression, but only very weak five These observations could provide additional criteria distinction between SCLC NSCLC. Furthermore, findings, based on tissues, implicate different mechanisms tumourigenesis
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