Fungicidal activity of copper-sputtered flexible surfaces under dark and actinic light against azole-resistant Candida albicans and Candida glabrata

作者: Myriam K.S. Ballo , Sami Rtimi , John Kiwi , César Pulgarin , José M. Entenza

DOI: 10.1016/J.JPHOTOBIOL.2017.07.030

关键词:

摘要: Abstract Candida spp. are able to survive on hospital surfaces and causes healthcare-associated infections (HCAIs). Since surface cleaning disinfecting interventions not totally effective eliminate spp., new approaches should be devised. Copper (Cu) has widely recognized antifungal activity the use of Cu-sputtered recently been proposed curb spread HCAIs. Moreover, Cu under action actinic light remains underexplored. We investigated polyester (Cu-PES) against azole-resistant albicans glabrata dark low intensity visible irradiation (4.65 mW/cm2). The properties Cu-PES photocatalysts were characterized by diffuse reflectance spectroscopy (DRS) X-ray fluorescence (XRF). Under dark, showed a fungicidal (≥ 3 log10 CFU reduction initial inoculum) both C. DSY296 DSY565 leading starting inoculum 3.1 3.0 log10 CFU, respectively, within 60 min exposure. irradiation, exhibited an accelerated strains with 3.0 3.4 log10 CFU, 30 min This effect was likely due semiconductor Cu2O/CuO charge separation. decrease in cell viability two conditions correlated progressive loss membrane integrity. These results indicate that represent promising strategy for decreasing colonization yeasts can improve its self-disinfecting activity.

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