Thalidomide therapy of established collagen-induced arthritis (CIA) not accompanied by an evident Th2 shift.

摘要: Thalidomide, a drug likely to affect the cytokine pattern, was administered orally mice at various stages of CIA. Treatment (150mg/kg per day by gavage, 5 days/week), started 6 weeks post-immunization, i.e. height disease, significantly reduced arthritis, and appeared also reduce level inflammation as judged neutrophil chemiluminescence. With treatment 9 post-immunization effect on arthritis no longer statistically significant, when 14 lost. Over dose range up 150mg/kg had either interferon-gamma (IFN-γ) or IL-4 mRNA levels. The is therefore not have operated via shift in Th1/Th2 balance.