A review on recent technologies for the manufacture of pulmonary drugs

摘要: This review discusses recent developments in the manufacture of inhalable dry powder formulations. Pulmonary drugs have distinct advantages compared with other drug administration routes. However, requirements properties complicate manufacture. Control over crystallization to make particles desired a single step is often infeasible, which calls for micronization techniques. Although spray drying produces size range, stable solid state may not be attainable. Supercritical fluids used as solvent or antisolvent, significantly reduces waste. Future directions include application areas such biopharmaceuticals inhalers and new processing strategies improve control particle formation continuous manufacturing in-line process analytical technologies.