Preparation, characterization and pulmonary pharmacokinetics of a new inhalable zanamivir dry powder

摘要: AbstractThis work describes a new dry powder for inhalation containing zanamivir, which is less hygroscopic than Relenza®. The powders were prepared via spray-drying technique using mannitol as the carrier. A 53 central composite design was used to optimize formulations. final optimized powders, characterized with an angle of repose 37.48°, aerodynamic diameter 2.346 μm and in vitro deposition 58.54%, obtained by predicted variable values. Relenza® absorbed significant amount water at 66%, 75% 85% relative humidity (RH; weight changes approximately 1.38%, 2.18% 3.72%, respectively). In contrast, change zanamivir (DPI) negligible when RH increased 66%. vivo potential studied further rats endotracheal administration 8.4 mg/kg dose. bioavailability 116% Fluorescence imaging monitored inhalers r...