Theophylline particle design using chitosan by the spray drying.

摘要: Abstract Solid dispersions of theophylline with chitosan as a carrier were prepared using spray-drying method. Chitosan dissolved in an acid solution forms gel, but it does not dissolve alkaline solution. Therefore, drugs which form composite particles would gradually be released solution, and are expected to have considerably sustained release In this study, we aimed apply ability pharmaceutics. used model drug carrier. Mixtures the prescribed ratios The physicochemical properties solid obtained investigated by powder X-ray diffraction, differential scanning calorimetry, dissolution rate analyses, view clarify effect crystallinity on rate. Furthermore, interaction between was FT-IR analysis. diffraction intensity spray-dried samples decreased increase contents, also caused changes from crystalline amorphous forms. These results indicated that system formed dispersion. profiles physical mixtures almost same at pH 1.2. However, 6.8, more than mixtures. spectroscopy for suggested carbonyl group amino hydrogen bond. Mass median aerodynamic diameter (MMAD) measured cascade impactor evaluate possibility dry inhalations. MMAD theophylline-chitosan systems 4.5–5.0 μm. method is usefull produce powders inhalation.