BMP4 supports noradrenergic differentiation by a PKA-dependent mechanism.

摘要: Abstract Differentiation of neural crest-derived noradrenergic neurons depends upon signaling mediated downstream BMP binding to cognate receptors and involving cAMP. Compiled data from many groups suggest that neurogenesis cell type-specific marker gene regulation is coordinated through the expression function basic helix–loop–helix DNA protein HAND2 homeodomain Phox2a. However, information detailing how BMP-mediated cAMP are has been lacking. We now provide compelling suggesting differentiation sympathetic ganglion both canonical non-canonical pathways signaling. The pathway involves activation kinase A (PKA) independent This a novel mechanism in cells necessary support as well aspects DBH promoter phosphorylation dimerization. transcripts encoding Phox2a regulated via thus affects expression. Interestingly, cAMP- MapK-mediated modulate specific target sites pathways. Activity MapK required for transcription neurogenesis. Signaling affected by transactivation HAND2. comprehensive model shows BMP- cAMP-mediated intracellular integrate function.