Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review.

摘要: Coffee and caffeine are mutagenic to bacteria fungi, in high concentrations they also mammalian cells culture. However, the effects of coffee disappear when or cultured presence liver extracts which contain detoxifying enzymes. In vivo, devoid effects. able interact with many other mutagens their synergistic X-rays, ultraviolet light some chemical agents. Caffeine seems potentiate rather than induce chromosomal aberrations transform sublethal damage agents into lethal damage. Conversely, inhibit numerous chemicals. These antimutagenic depend on time administration as compared acting agent. that case, be restore normal cycle mitosis phosphorylation irradiated cells. Finally, potential genotoxic most important constituents reviewed. Mutagenicity is mainly attributed chemically reactive components such aliphatic dicarbonyls. The latter compounds, formed during roasting process, but less Hydrogen peroxide not very active considerably enhance properties methylglyoxal. Phenolic compounds anticarcinogenic. Benzopyrene pyrolysis whereas beans at temperature generates heterocyclic amines. conclusion, has been demonstrated lower organisms, usually doses several orders magnitude greater estimated dose for humans. Therefore, chances consumption moderate amounts humans almost nonexistent.