Leptomeningeal carcinomatosis: prognostic implications of clinical and cerebrospinal fluid features.

摘要: BACKGROUND Leptomeningeal carcinomatosis (LC) represents a devastating complication of systemic cancer, and patients with LC have dismal prognosis increased mortality. The few studies that focused on the evaluation prognostic factors in resulted contradictory results. Thus, treatment remains controversial, no straightforward guidelines exist literature. objective current study was to identify markers related survival better select who are eligible for intensive treatment. METHODS Seventy had diagnosis were reviewed, clinical data, cerebrospinal fluid (CSF) parameters, tumor-related characteristics, information registered. impact single parameters overall determined by both univariate multivariate analyses. RESULTS analysis revealed Radiation Therapy Oncology Group score or=2.7 mmol/L (P=.001), presence infratentorial symptoms at onset (P=.026), intrathecal (P<.001) associated independently longer LC. In addition, same also predicted response such patients. CONCLUSIONS predictive identified this could help more likely benefit from chemotherapy.