Sensitivity and specificity of intracoronary injection of acetylcholine for the induction of coronary artery spasm.

摘要: Intracoronary injection of acetylcholine has been shown to induce coronary spasm in patients with variant angina. To examine its sensitivity and specificity, incremental doses (20, 50 100 micrograms into the left artery 20 right artery) were injected or arteries 70 angina (Group 1) (mean age 57 years) 93 without at rest 2) 54 years). Forty latter group had atypical chest pain, 16 cardiomyopathy, 14 arrhythmia, 11 valvular disease, 7 stable effort due advanced 3 congenital heart disease 2 hypertension. A temporary cardiac pacemaker set 40 beats/min was positioned ventricle. Coronary defined as total occlusion severe vasoconstriction associated pain ischemic ST changes on electrocardiogram both. In Group 1, induced 63 (90%) predicted be responsible for spontaneous attacks. 2, only one patient although lesser degrees (less than equal 75% luminal diameter) occurred most after (specificity thus 99%). conclusion, intracoronary is sensitive reliable induction spasm.