Small-molecule modulators of c-Myc/Max and Max/Max interactions.
作者： Thorsten Berg
DOI: 10.1007/82_2010_90
关键词:
摘要: The transcription factor c-Myc is overexpressed in many tumors human beings and has been identified as a highly promising target for cancer therapy. Most biological functions of require heterodimerization with its activation partner Max. Inhibition the protein–protein interactions between Max by small molecules shown to be feasible powerful approach toward inhibition functions. More recently, stabilization homodimers reduce amount available activating also demonstrated counteract Myc activity. This review summarizes our current knowledge on organic that inhibit modulating relevant function this important oncoprotein.
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