Genetic polymorphisms of the RAS-cytokine pathway and chronic kidney disease

摘要: Chronic kidney disease (CKD) in children is irreversible. It associated with renal failure progression and atherosclerotic cardiovascular (CV) abnormalities. Nearly 60% of CKD are affected since birth congenital or inherited disorders. Preliminary evidence primarily from adult studies indicates common genetic risk factors for CV disease. Although multiple physiologic pathways share genes disease, substantial supports our attention to the renin angiotensin system (RAS) interlinked inflammatory cascade because they modulate progressions Gene polymorphisms RAS-cytokine pathway, through altered gene expression cytokines, potential that rate abnormalities patients CKD. For studying such hypotheses, cooperative efforts among scientific groups availability robust affordable technologies genotype thousands single nucleotide (SNPs) across genome make genome-wide association an attractive paradigm polygenic diseases as attractive, should be interpreted carefully, a fundamental understanding their weaknesses. Nevertheless, whole-genome diabetic nephropathy future pertaining other types will offer further insight development targeted interventions treat pediatric population.