Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.

摘要: Aim: The endothel dysfunction in early life may play a role developmental programming of cardiovascular morbidity. changes dimethylarginines' plasma levels during the first month among preterm infants and their determinants had been investigated our study. Methods: Twenty healthy mothers were studied. Mean (±SD) birth weight gestational age 919.5 ± 235.5 g 26.7 1.6 weeks, respectively. Blood samples taken by venipuncture at 3rd, 7th, 14th, 21st 28th days. Plasma concentrations L-arginine, asymmetric symmetric dimethylarginine (SDMA) measured liquid chromatography-mass spectrometry method, evaluated multivariate linear regression analysis. Results: L-arginine (p < 0.001) (ADMA) positively associated with postnatal age. ADMA negatively correlated = 0.007), dopamine-need on 3rd day 0.015) late infection 0.038). higher was 0.052) 0.002) concentrations. 7th significant effect elevation SDMA 0.035). Conclusion: progressive increase described study suggests that take part chronic adult diseases.