The role of hydrogen sulfide in gastric mucosal damage.

作者: Fang Shen , Chong-Shun Zhao , Mei-Fen Shen , Zhong Wang , Gang Chen

DOI: 10.4103/2045-9912.260650

关键词:

摘要: Gastrointestinal disease is a major global threat to public health. In the past few decades, numerous studies have focuses on application of small molecule gases in treatment. Increasing evidence has shown that hydrogen sulfide (H2S) anti-inflammatory and anti-oxidative effects, can regulate gastric mucosal blood flow mucosa. After mucosa damage, level H2S stomach decreases. Administration protect repair damaged Therefore, new target for treatment damage. this review, we introduce roles damage provide potential strategies further clinical

参考文章(51)
Marcus W. Warenycia, Lorne R. Goodwin, Christina G. Benishin, R.J. Reiffenstein, Donna M. Francom, Jack D. Taylor, Fred P. Dieken, Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels. Biochemical Pharmacology. ,vol. 38, pp. 973- 981 ,(1989) , 10.1016/0006-2952(89)90288-8
Marcin Magierowski, Katarzyna Magierowska, Slawomir Kwiecien, Tomasz Brzozowski, Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules. ,vol. 20, pp. 9099- 9123 ,(2015) , 10.3390/MOLECULES20059099
Jifang Zheng, Tingting Zhao, Yan Yuan, Nan Hu, Xiaoqing Tang, Hydrogen sulfide (H2S) attenuates uranium-induced acute nephrotoxicity through oxidative stress and inflammatory response via Nrf2-NF-κB pathways. Chemico-Biological Interactions. ,vol. 242, pp. 353- 362 ,(2015) , 10.1016/J.CBI.2015.10.021
Ling Li, Giuseppe Rossoni, Anna Sparatore, Lin Chiou Lee, Piero Del Soldato, Philip Keith Moore, Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radical Biology and Medicine. ,vol. 42, pp. 706- 719 ,(2007) , 10.1016/J.FREERADBIOMED.2006.12.011
Mariarosaria Bucci, Andreas Papapetropoulos, Valentina Vellecco, Zongmin Zhou, Altaany Zaid, Panagiotis Giannogonas, Anna Cantalupo, Sandeep Dhayade, Katia P. Karalis, Rui Wang, Robert Feil, Giuseppe Cirino, cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0053319
Stefano Fiorucci, Eleonora Distrutti, Giuseppe Cirino, John L. Wallace, The Emerging Roles of Hydrogen Sulfide in the Gastrointestinal Tract and Liver Gastroenterology. ,vol. 131, pp. 259- 271 ,(2006) , 10.1053/J.GASTRO.2006.02.033
Esam M. Aboubakr, Ashraf Taye, Mohamed A. El-Moselhy, Magdy K. Hassan, Protective effect of hydrogen sulfide against cold restraint stress-induced gastric mucosal injury in rats. Archives of Pharmacal Research. ,vol. 36, pp. 1507- 1515 ,(2013) , 10.1007/S12272-013-0194-3
John L. Wallace, Rui Wang, Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter Nature Reviews Drug Discovery. ,vol. 14, pp. 329- 345 ,(2015) , 10.1038/NRD4433
Marisol Chang, Jing Xue, Vishal Sharma, Aida Habtezion, Protective role of hemeoxygenase-1 in gastrointestinal diseases Cellular and Molecular Life Sciences. ,vol. 72, pp. 1161- 1173 ,(2015) , 10.1007/S00018-014-1790-1