A comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on superovulation in Asian women with normal ovulatory cycles.

作者: Chutima Topipat , Wicharn Choktanasiri , Rattiya Jultanmas , Sawaek Weerakiet , Anna Wongkularb

DOI: 10.1080/09513590801895609

关键词:

摘要: Objective. To compare the effect of aromatase inhibitor letrozole and clomiphene citrate (CC) on superovulation in women with normal ovulation.Methods. A cross-over randomized study 22 ovulation, divided randomly into two equal cohorts, was carried out. Each group 11 allocated to take or CC for one cycle. After washing out cycle, alternative drug administered subsequent The number size mature follicles, endometrial thickness, estradiol progesterone levels were monitored.Results. follicles ovulation day significantly lower than (p < 0.05 both). However, no differences between groups thickness pattern observed. Progesterone showed all cycles.Conclusions. administration 50 mg days 3–5 superior 2.5 induction w...

参考文章(42)
DavidS Guzick, MichaelW Sullivan, G.David Adamson, MarcelleI Cedars, RichardJ Falk, EdwinP Peterson, MichaelP Steinkampf, Efficacy of treatment for unexplained infertility Fertility and Sterility. ,vol. 70, pp. 207- 213 ,(1998) , 10.1016/S0015-0282(98)00177-0
R. Dickey, Development, pharmacology and clinical experience with clomiphene citrate Human Reproduction Update. ,vol. 2, pp. 483- 506 ,(1996) , 10.1093/HUMUPD/2.6.483
Robert F. Casper, Aromatase inhibitors in ovarian stimulation The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 106, pp. 71- 75 ,(2007) , 10.1016/J.JSBMB.2007.05.025
W.R Al-Omari, W.R Sulaiman, N Al-Hadithi, Comparison of two aromatase inhibitors in women with clomiphene-resistant polycystic ovary syndrome. International Journal of Gynecology & Obstetrics. ,vol. 85, pp. 289- 291 ,(2004) , 10.1016/J.IJGO.2003.11.010
James H. Clark, Sylvia C. Guthrie, Agonistic and Antagonistic Effects of Clomiphene Citrate and Its Isomers Biology of Reproduction. ,vol. 25, pp. 667- 672 ,(1981) , 10.1095/BIOLREPROD25.3.667
S. Haritha, G. Rajagopalan, Follicular growth, endometrial thickness, and serum estradiol levels in spontaneous and clomiphene citrate-induced cycles International Journal of Gynecology & Obstetrics. ,vol. 81, pp. 287- 292 ,(2003) , 10.1016/S0020-7292(02)00404-6
Mohamed Farouk M Mitwally, Robert F Casper, Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders Fertility and Sterility. ,vol. 77, pp. 776- 780 ,(2002) , 10.1016/S0015-0282(01)03280-0
Stephanie A Fisher, Robert L Reid, Dean A Van Vugt, Robert F Casper, A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women. Fertility and Sterility. ,vol. 78, pp. 280- 285 ,(2002) , 10.1016/S0015-0282(02)03241-7
James H. Clark, Barry M. Markaverich, The agonistic-antagonistic properties of clomiphene: A review Pharmacology & Therapeutics. ,vol. 15, pp. 467- 519 ,(1981) , 10.1016/0163-7258(81)90055-3
U BAYAR, M BASARAN, S KIRAN, A COSKUN, S GEZER, Use of an aromatase inhibitor in patients with polycystic ovary syndrome: a prospective randomized trial. Fertility and Sterility. ,vol. 86, pp. 1447- 1451 ,(2006) , 10.1016/J.FERTNSTERT.2006.04.026