Evaluation of Minimal Residual Disease (MRD) in Children with T-Lineage Acute Lymphoblastic Leukemia

作者: J. Peregud-Pogorzelski , J. Lubinski , A. Brodkiewicz , A. Jakubowska , R. Debski

DOI: 10.1007/978-3-642-59358-1_55

关键词:

摘要: In acute leukemias malignant cells derived from the sole parent cell that underwent neoplastic transformation share identical configuration of Ig and TCR genes. Monoclonal rearrangements genes comprise unique features given leukemic clone, thus allowing basis for monitoring minimal residual disease (MRD) using polymerase chain reaction (PCR) method in lymphoblastic [1,4,7,14,22]. Results several clinical studies indicate detection ALL correlates positively with relapse [5,10,14,20, 21,22]. Acute T-cell leukemia is a clinically homogenous high rate treatment failures. Thus, immunophenotype considered as an unfavourable prognostic factor. Intensification group patients produced current results comparable those achieved non- T-ALL [14,15,16]. Occurrence reflects ineffectiveness chemotherapy allogenic bone marrow transplantation probably only chance cure. Ability to identify population at risk would allow early alternative treatment. context TCRδ TCRγ gene represent optimal target MRD PCR assay T-ALL, since least one allele rearranged 95% remains stable more than 90% cases [3], Also rearrangements, present 70% show limited potential variety, use procedures detect positive results, vast diversity junctional sites allows preparation patient- specific probes [2,3], Studies performed by Dibenedetto et al. showed might be detected test 12-15 weeks after completion induction therapy almost all (94%), regardless protocol [8]. Their analysis confirms observation presence 30-40 diagnosis predictor poor prognosis. On contrary, lack any time point correlated favourable this prospective study we investigated 18 childhood various points BFM 90 protocol. We applied previously described Vandenvelde Taylor [18,19]. The aim was answer question whether children influence outcome.

参考文章(22)
M Deane, K P McCarthy, L M Wiedemann, John D Norton, An improved method for detection of B-lymphoid clonality by polymerase chain reaction Leukemia. ,vol. 5, pp. 726- 730 ,(1991)
M. Duys, C. Vandenvelde, D. Van Beers, R. Scheen, F. Corazza, Fast PCR based therapeutic follow-up of T-cell malignancies. Nouvelle revue française d'hématologie. ,vol. 33, pp. 293- 297 ,(1991)
H Cave, C Guidal, P Rohrlich, MH Delfau, A Broyart, B Lescoeur, C Rahimy, O Fenneteau, N Monplaisir, L d'Auriol, None, Prospective monitoring and quantitation of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of delta and gamma T-cell receptor genes. Blood. ,vol. 83, pp. 1892- 1902 ,(1994) , 10.1182/BLOOD.V83.7.1892.1892
TM Breit, IL Wolvers-Tettero, A Beishuizen, MA Verhoeven, ER van Wering, JJ van Dongen, Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia Blood. ,vol. 82, pp. 3063- 3074 ,(1993) , 10.1182/BLOOD.V82.10.3063.3063
M A Schorin, S Blattner, R D Gelber, N J Tarbell, M Donnelly, V Dalton, H J Cohen, S E Sallan, Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber Cancer Institute/Children's Hospital Acute Lymphoblastic Leukemia Consortium Protocol 85-01. Journal of Clinical Oncology. ,vol. 12, pp. 740- 747 ,(1994) , 10.1200/JCO.1994.12.4.740
Keith P. McCarthy, John P. Sloane, Janusz H.S. Kabarowski, Estela Matutes, Leanne M. Wiedemann, A simplified method of detection of clonal rearrangements of the T-cell receptor-gamma chain gene. Diagnostic Molecular Pathology. ,vol. 1, pp. 173- 179 ,(1992) , 10.1097/00019606-199203000-00025
M. J. Brisco, J. Condon, P. J. Sykes, S. H. Neoh, A. A. Morley, Detection and quantitation of neoplastic cells in acute lymphoblastic leukaemia, by use of the polymerase chain reaction British Journal of Haematology. ,vol. 79, pp. 211- 217 ,(1991) , 10.1111/J.1365-2141.1991.TB04524.X
T Szczepański, AW Langerak, ILM Wolvers-Tettero, GJ Ossenkoppele, G Verhoef, M Stul, EJ Petersen, MAC de Bruijn, MB van’t Veer, JJM van Dongen, Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease Leukemia. ,vol. 12, pp. 1081- 1088 ,(1998) , 10.1038/SJ.LEU.2401071
Y. Nizet, P. Martiat, J. L. Vaerman, M. Philippe, C. Wildmann, J. P. Staelens, G. Cornu, A. Ferrant, J. L. Michaux, G. Sokal, Follow-up of residual disease (MRD) in B lineage acute leukaemias using a simplified PCR strategy: evolution of MRD rather than its detection is correlated with clinical outcome. British Journal of Haematology. ,vol. 79, pp. 205- 210 ,(1991) , 10.1111/J.1365-2141.1991.TB04523.X
M Smith, D Arthur, B Camitta, A J Carroll, W Crist, P Gaynon, R Gelber, N Heerema, E L Korn, M Link, S Murphy, C H Pui, J Pullen, G Reamon, S E Sallan, H Sather, J Shuster, R Simon, M Trigg, D Tubergen, F Uckun, R Ungerleider, Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Journal of Clinical Oncology. ,vol. 14, pp. 18- 24 ,(1996) , 10.1200/JCO.1996.14.1.18