Membrane lectins on human monocytes: Maturation-dependent modulation of 6-phosphomannose and mannose receptors

作者: Annie-Claude Roche , Patrick Midoux , Philippe Bouchard , Michel Monsigny

DOI: 10.1016/0014-5793(85)80080-6

关键词:

摘要: Freshly isolated human monocytes, which do not contain cell-surface mannose-specific receptors, bind mannose 6-phosphate and actively endocytose 6-phosphate-bearing neoglycoproteins (6-P-Man-F-BSA). Three days after isolation, monocytes very 6-P-Man-F-BSA as well Man-F-BSA, the endocytosed are rapidly degraded. These results were obtained in quantitative flow cytofluorometry by using a panel of fluoresceinylated sugar-substituted serum albumins (neoglycoproteins). Thus, contrast to receptors appear only maturation, already present on freshly monocytes.

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