Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

摘要: Background The effect of grape polyphenols on blood pressure remains unclear, which we aimed to address via a meta-analysis study. Methods We conducted study trial searches in PubMed, Embase, and the Cochrane Library databases. Summary estimates weighted mean differences 95% confidence intervals were obtained by using fixed-effects models. Subgroup analyses performed identify source heterogeneity. The protocol details our have been submitted international database prospectively registered systematic reviews (registration number CRD42015019196). Results Ten studies included present meta-analysis. Our results showed daily polyphenol intake could significantly reduce systolic 1.48 mmHg when compared control subjects (12 comparisons; -1.48 [-2.79 -0.16] mmHg; P = 0.03). indicated larger reduction was identified low-dose (< 733 mg/day, median level studies) or patients with metabolic syndrome. Contrarily, diastolic not decreased group as controls. No significant heterogeneity publication bias detected either pressure. Conclusions Daily can humans, although is modest anti-hypertensive medications. Larger, better designed trials, that specifically include hypertensive subjects, are required verify future.