Penicilinoterapia intravenosa em altas doses na neurossífilis: estudo de 62 casos II. Avaliação do líqüido cefalorraqueano

摘要: Sixty-two patients with symptomatic neurosyphilis were treated 20 or 24 megaunits of intravenous penicillin G daily for 15 to 30 days. The mean follow-up time after the treatment was months. Forty-one had pleocytosis in CSF before treatment. Six months and twelve more later, abnormal cell count observed 4 (9.8%) 3 (7.3%), respectively. protein level titers Wassermann reaction decreased slowly gammaglobulin concentration immunoglobulin production inside blood-brain barrier still increased beyond first year results these high doses not different from verified lesser intramuscular that reported literature.