6,7-Dihydroxytetrahydroisoquinoline: uptake and storage by peripheral sympathetic nerve of the rat.
作者： G. Cohen , C. Mytilineou , R. E. Barrett
DOI: 10.1126/SCIENCE.175.4027.1269
关键词:
摘要: 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline is a pharmacologically active alkaloid that can be formed by condensation of dopamine with formaldehyde. We used fluorescence microscopy to study in vitro the uptake and storage this compound sympathetic nerves rat iris. Rats were treated reserpine or methyl ester α-methyl-p-tyrosine order deplete endogenous catecholamine stores. Accumulation was about onetenth norepinephrine. Uptake completely blocked 10-5M desmethylimipramine. These results offer some explanation for sympathomimetric properties alkaloid. Similar expected similar tetrahydroisoquinolines may vivo from catecholamines during ingestion alcoholic beverages.
sciencemag.org
harvard.edu参考文章(14)
Edwin J. Debeer, Axel M. Hjort, David W. Fassett, SOME TETRAHYDROISOQUINOLINES IV. THE CIRCULATORY ADRENOLYTIC EFFECTS Journal of Pharmacology and Experimental Therapeutics. ,vol. 68, pp. 73- 79 ,(1940)
YASUMITSU YAMANAKA, MICHAEL J. WALSH, VIRGINIA E. DAVIS, Salsolinol, an Alkaloid Derivative of Dopamine formed in vitro during Alcohol Metabolism Nature. ,vol. 227, pp. 1143- 1144 ,(1970) , 10.1038/2271143A0
Annica Dahlström, Jan Häogendal, Tomas Hökfelt, The noradrenaline content of the varicosities of sympathetic adrenergic nerve terminals in the rat. Acta Physiologica Scandinavica. ,vol. 67, pp. 289- 294 ,(1966) , 10.1111/J.1748-1716.1966.TB03314.X
Kjell Fuxe, Urban Ungerstedt, Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine European Journal of Pharmacology. ,vol. 4, pp. 135- 144 ,(1968) , 10.1016/0014-2999(68)90169-6
G. Cohen, M. Collins, Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism Science. ,vol. 167, pp. 1749- 1751 ,(1970) , 10.1126/SCIENCE.167.3926.1749
Gerald Cohen, Tetrahydroisoquinoline alkaloids in the adrenal medulla after perfusion with “blood concentrations” of [14C]acetaldehyde Biochemical Pharmacology. ,vol. 20, pp. 1757- 1761 ,(1971) , 10.1016/0006-2952(71)90373-X
Gosta Jonsson, Charlotte Sachs, Subcellular Distribution of 3H‐noradrenaline in Adrenergic Nerves of Mouse Atrium — Effect of Reserpine, Monoamine Oxidase and Tyrosine Hydroxylase Inhibition Acta Physiologica Scandinavica. ,vol. 77, pp. 344- 357 ,(1969) , 10.1111/J.1748-1716.1969.TB04579.X
Axel M. Hjort, Edwin J. De Beer, David W. Fassett, SOME TETRAHYDROISOQUINOLINES III. THE RELATIVE ANTIANESTHETIC EFFECTS Journal of Pharmacology and Experimental Therapeutics. ,vol. 63, pp. 432- 437 ,(1938)
Edwin J. Debeer, Axel M. Hjort, David W. Fassett, SOME TETRAHYDROISOQUINOLINES A NOTE ON THE RELATIVE LETHAL AND CIRCULATORY EFFECTS OF SOME 2-ALKYL DERIVATIVES Journal of Pharmacology and Experimental Therapeutics. ,vol. 68, pp. 69- 72 ,(1940)
Gerald Cohen, Richard Heikkila, Dorothy Dembiec, TETRAHYDROISOQUINOLINE ALKALOIDS: UPTAKE BY RAT BRAIN HOMOGENATES AND INHIBITION OF CATECHOLAMINE UPTAKE Journal of Pharmacology and Experimental Therapeutics. ,vol. 179, pp. 250- 258 ,(1971)