The design and synthesis of mimetics of peptide beta-turns.
作者： Michael Kahn , Susanne Wilke , Barbara Chen , Kagari Fujita , Yu-Hwei Lee
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摘要: The synthesis of an 11 membered ring bis-lactam, a system which is designed as conformationally restricted mimetic type I and II beta-turns described. Computer assisted molecular modeling was used to compare the predicted low energy conformers turn with idealized structures. Initial computational analysis indicates that basic structure will provide excellent foundation for development varieity beta-turn mimetics.
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