Keratoconus corneas: Increased gelatinolytic activity appears after modification of inhibitors
作者： D. Brown , M. M. Chwa , A. Opbroek , M. C. Kenney
DOI: 10.3109/02713689309001835
关键词:
摘要: We examined the metalloproteinase activity from normal and keratoconus corneal extracts. No differences were detected in total amount of or its physical form activation. However, there was a significant elevation enzymatic extracts after chemical modification inhibitory elements. This suggests either difference capabilities corneas or, as suggested previously, decrease TIMP (tissue inhibitor metalloproteinase) present tissue.
informahealthcare.com参考文章(28)
M T Girard, M E Fini, Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 1779- 1788 ,(1990)
J D Zieske, M Matsubara, M E Fini, Mechanism of basement membrane dissolution preceding corneal ulceration Investigative Ophthalmology & Visual Science. ,vol. 32, pp. 3221- 3237 ,(1991)
Jay H. Krachmer, John R. Hassell, Stephen I. Katz, Jean-Michel Foidart, Merlyn M. Rodrigues, David A. Newsome, Detection of specific collagen types in normal and keratoconus corneas. Investigative Ophthalmology & Visual Science. ,vol. 20, pp. 738- 750 ,(1981)
M S Hibbs, K A Hasty, J M Seyer, A H Kang, C L Mainardi, Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase. Journal of Biological Chemistry. ,vol. 260, pp. 2493- 2500 ,(1985) , 10.1016/S0021-9258(18)89580-1
P W Ledger, S K Nishimoto, S Hayashi, M L Tanzer, Abnormal glycosylation of human fibronectin secreted in the presence of monensin. Journal of Biological Chemistry. ,vol. 258, pp. 547- 554 ,(1983) , 10.1016/S0021-9258(18)33289-7
W G Stetler-Stevenson, H C Krutzsch, L A Liotta, Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. Journal of Biological Chemistry. ,vol. 264, pp. 17374- 17378 ,(1989) , 10.1016/S0021-9258(18)71503-2
T E Cawston, W A Galloway, E Mercer, G Murphy, J J Reynolds, Purification of rabbit bone inhibitor of collagenase Biochemical Journal. ,vol. 195, pp. 159- 165 ,(1981) , 10.1042/BJ1950159
Winston Whei-Yang Kao, Jean-Paul Vergnes, Jonathan Ebert, C.V. Sundar-Raj, Stuart I. Brown, Increased collagenase and gelatinase activities in keratoconus. Biochemical and Biophysical Research Communications. ,vol. 107, pp. 929- 936 ,(1982) , 10.1016/0006-291X(82)90612-X
James G. Weeks, Jouku Halme, J.Frederick Woessner, Extraction of collagenase from the involuting rat uterus Biochimica et Biophysica Acta (BBA) - Enzymology. ,vol. 445, pp. 205- 214 ,(1976) , 10.1016/0005-2744(76)90173-X
B. Y. J. T. Yue, J. Sugar, K. Benveniste, Heterogeneity in Keratoconus: Possible Biochemical Basis: Experimental Biology and Medicine. ,vol. 175, pp. 336- 341 ,(1984) , 10.3181/00379727-175-41804