DETERMINATION AND PHARMACOKINETICS OF MEXILETINE IN RABBIT PLASMA BY GAS CHROMATOGRAPHY WITH MASS SPECTROMETRY
作者： Bilal Yilmaz
DOI: 10.1080/00032711003725623
关键词:
摘要: This paper describes a gas chromatography/mass spectrophotometry method for determination of mexiletine in rabbit plasma. Mexiletine and internal standard metoprolol were extracted from plasma with mixture ethylacetate diethylether at basic pH liquid-liquid extraction. Calibration curves linear over the concentration range 45–2000 ng/mL. Intra- inter-day precision (relative deviation) less than 6.9%, accuracy error) was better 6.8%. Recovery averaged 92.6%. successfully applied to six rabbits which had given an oral capsule 200 mg mexiletine.
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