The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children.

摘要: Background Nesfatin-1, a recently discovered anorexigenic neuropeptide, is expressed in several tissues including pancreatic islet cells and central nervous system. This peptide seems to play an important role hypothalamic pathways regulating food intake energy homeostasis. Objective We aimed investigate the relation of serum nesfatin-1 level with metabolic anthropometric parameters obese children. Methods The study included children body mass index (BMI) above 95th percentile healthy BMI below 85th percentile. The subjects had similar age gender distribution. Fasting glucose, insulin, lipid profile, levels were measured evaluate parameters. Results Obese group (n = 37) significantly higher BMI, BMI-SDS (standard deviation score BMI), triglyceride, insulin resistance by homeostasis model assessment, systolic diastolic blood pressure values compared control (n = 31) (p < 0.05). Serum was lower than that (p = 0.001). No statistically significant difference found when among patients regarding presence (p = 0.202). In group, negatively correlated BMI-SDS, but not (p = 0.02 p = 0.361, respectively). Conclusions This first who levels. Our results underline may regulation individuals.