HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments.
作者： Kathleen A. Connell , Marsha K. Guess , Heidi W. Chen , Tara Lynch , Richard Bercik
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摘要: The uterosacral ligaments (USLs) are key support structures of the uterus and upper vagina. Previously, we have shown that HOXA11 is necessary for development USLs, deficient in women with pelvic organ prolapse (POP) regulates expression extracellular matrix (ECM) proteins. Here sought to determine if cell proliferation USLs women. Like others, found that, there decreased cellularity prolapsed compared normal support. We also demonstrated promotes murine fibroblasts primary human USL cells vitro. These findings a relationship between expression, rates phenotypic abnormalities USL. Based on these findings, p53, tumor suppressor gene which controls progression through cycle ECM genes. represses p...
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