Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse

作者: Boris Gabriel , Dirk Watermann , Katharina Hancke , Gerald Gitsch , Martin Werner

DOI: 10.1007/S00192-005-0045-Y

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摘要: The uterosacral ligaments are an important part of the pelvic support system and connective tissue alterations thought to contribute development organ prolapse (POP). objective this study was compare expression matrix metalloproteinases (MMPs) 1 2 in these women with without POP. We analyzed samples obtained from left and/or right 17 POP 18 controls by immunohistochemistry. There no difference MMP-1 between those without. In contrast, MMP-2 significantly related presence (p=0.004) rather than age or parity. compared controls. Our findings strongly indicate that increased is associated

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