Pelvic floor disorders: linking genetic risk factors to biochemical changes
作者： Lysanne Campeau , Ilya Gorbachinsky , Gopal H. Badlani , Karl Erik Andersson
DOI: 10.1111/J.1464-410X.2011.10385.X
关键词:
摘要: Pelvic floor disorders (PFDs) such as stress urinary incontinence (SUI) and pelvic organ prolapse (POP) may share a common pathophysiological process related to tissue laxity loss of support. We reviewed recent literature on observed biochemical changes in women with SUI POP, linking them genetic predisposition. found that studies tissues showed differences between control subjects POP collagen elastin structure at molecular fibrillar level. Studies were heterogeneous but trend towards decreased content. The contribution matrix metalloproteinases increased collagenolysis can be polymorphisms present higher frequency PFD. Extracellular (ECM) protein turnover plays role the development SUI, much remains understood this complex dynamic interplay enzymes, proteins molecules. Genotyping candidate genes participating ECM formation will elucidate missing link manifestation disease systematically, addition those floor.
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