摘要: Epithelial cells, and the tight junctions between them, form a polarized barrier luminal serosal fluid compartments segregate growth factors from their basal-lateral receptors. Breakdown of this should allow access in to receptors on cell membranes, as recently demonstrated for heregulin erbB airway epithelia. It also stroma. This property may have adaptive value epithelial tissues general, an elegant response injury, but promote cancer formation premalignant which become chronically leaky factors.
sciencemag.org参考文章(52)
R. K. Rao, D. W. Thomas, S. Pepperl, F. Porreca, Salivary epidermal growth factor plays a role in protection of ileal mucosal integrity. Digestive Diseases and Sciences. ,vol. 42, pp. 2175- 2181 ,(1997) , 10.1023/A:1018855525989
H. Gregory, S. Walsh, C.R. Hopkins, The identification of urogastrone in serum, saliva, and gastric juice. Gastroenterology. ,vol. 77, pp. 313- 318 ,(1979) , 10.1016/0016-5085(79)90284-1
J. F. Thompson, Specific receptors for epidermal growth factor in rat intestinal microvillus membranes American Journal of Physiology-Gastrointestinal and Liver Physiology. ,vol. 254, pp. G429- G435 ,(1988) , 10.1152/AJPGI.1988.254.3.G429
Joseph Alroy, Tight junctions adjacent to tumor stromal interface in human invasive transitional cell carcinomas. Virchows Archiv B Cell Pathology Including Molecular Pathology. ,vol. 30, pp. 289- 296 ,(1979) , 10.1007/BF02889109
L Gonzalez-Mariscal, A Betanzos, P Nava, BE Jaramillo, Tight junction proteins. Progress in Biophysics & Molecular Biology. ,vol. 81, pp. 1- 44 ,(2003) , 10.1016/S0079-6107(02)00037-8
W. P. Bishop, J. T. Wen, Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 267, ,(1994) , 10.1152/AJPGI.1994.267.5.G892
Patricia Buse, Paul L. Woo, David B. Alexander, Helen H. Cha, Avid Reza, Naalla D. Sirota, Gary L. Firestone, Transforming Growth Factor-α Abrogates Glucocorticoid-stimulated Tight Junction Formation and Growth Suppression in Rat Mammary Epithelial Tumor Cells Journal of Biological Chemistry. ,vol. 270, pp. 6505- 6514 ,(1995) , 10.1074/JBC.270.12.6505
V. Dodane, B. Kachar, Identification of isoforms of G proteins and PKC that colocalize with tight junctions. The Journal of Membrane Biology. ,vol. 149, pp. 199- 209 ,(1996) , 10.1007/S002329900020
P A Gonnella, K Siminoski, R A Murphy, M R Neutra, Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum. Journal of Clinical Investigation. ,vol. 80, pp. 22- 32 ,(1987) , 10.1172/JCI113051
James M. Mullin, Mary T. McGinn, The phorbol ester, TPA, increases transepithelial epidermal growth factor flux FEBS Letters. ,vol. 221, pp. 359- 364 ,(1987) , 10.1016/0014-5793(87)80956-0