Expression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expression
作者： Li-Yu Lee , Ying Liang , Chi-Ming Wu , Chee-Chan Wang , Jau-Song Yu
DOI: 10.14670/HH-23.515
关键词:
摘要: Matrix metalloproteinases (MMPs) MMP-2 and MMP-9 can degrade type IV collagen of extracellular matrix basal membranes. Claudin-4 is a member large family transmembrane proteins, claudins, essential in the formation maintenance tight junctions. has been shown to activate MMP-2, indicating that claudin-mediated increased cancer cell invasion might be mediated through activation MMP proteins. To explore roles claudin-4 gastric cancer, we selected 88 cases then analyzed expression these proteins using immunohistochemistry. We found all expressions were significantly higher intestinal-type than diffuse-type cancer. On further analysis, testing relationship between with expression, was associated but not expression. The results showed may phenotypic features, distinguishing Possibly, played role determining activity which favored distal metastasis.
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Boag Ah, Young Id, Increased expression of the 72-kd type IV collagenase in prostatic adenocarcinoma. Demonstration by immunohistochemistry and in situ hybridization. American Journal of Pathology. ,vol. 144, pp. 585- 591 ,(1994)
Ian M. P. Dawson, Basil C. Morson, Morson & Dawson's Gastrointestinal Pathology ,(1990)
Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh, Multifunctional strands in tight junctions. Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 285- 293 ,(2001) , 10.1038/35067088
L Gonzalez-Mariscal, A Betanzos, P Nava, BE Jaramillo, Tight junction proteins. Progress in Biophysics & Molecular Biology. ,vol. 81, pp. 1- 44 ,(2003) , 10.1016/S0079-6107(02)00037-8
Wen Guo Jiang, Tracey Amanda Martin, Tight junctions and their role in cancer metastasis. Histology and Histopathology. ,vol. 16, pp. 1183- 1195 ,(2001) , 10.14670/HH-16.1183
V. Ravn, B. Bruun Rasmussen, L. Højholt, M. Barfoed, I. Heiberg, S.M. Thorpe, Reproducibility of subjective immunohistochemical estrogen- and progesterone receptor determination in human endometrium. Pathology Research and Practice. ,vol. 189, pp. 1015- 1022 ,(1993) , 10.1016/S0344-0338(11)80674-6
Yasuhiko Umehara, Taizou Kimura, Masayuki Yoshida, Noriyuki Oba, Yukio Harada, Metastatic mode of gastric carcinoma by flow cytometric and clinicopathologic parameters Clinical & Experimental Metastasis. ,vol. 10, pp. 19- 24 ,(1992) , 10.1007/BF00163572
J. M. Mullin, Epithelial Barriers, Compartmentation, and Cancer Science Signaling. ,vol. 2004, ,(2004) , 10.1126/STKE.2162004PE2
S. J. Urbanski, D. R. Edwards, N. Hershfield, S. A. Huchcroft, E. Shaffer, L. Sutherland, A. E. Kossakowska, Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia. Diagnostic Molecular Pathology. ,vol. 2, pp. 81- 89 ,(1993) , 10.1097/00019606-199300020-00013
Yoshihiko Sakurai, Yoshihide Otani, Kaori Kameyama, Yasuhiro Hosoda, Isao Okazaki, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima, Expression of Interstitial Collagenase (Matrix Metalloproteinase-1) in Gastric Cancers Japanese Journal of Cancer Research. ,vol. 88, pp. 401- 406 ,(1997) , 10.1111/J.1349-7006.1997.TB00396.X