Portal hypertension in chronic hepatitis: relationship to morphological changes.

摘要: Various anatomical factors were examined which might provide passive resistance to portal venous flow and so cause hypertension. Methods included the measurement of pressure (WHVPG) in cirrhotic non-cirrhotic patients, morphological assessment by semiquantitative grading severity disease, calculation hepatocyte size indices, volume density hepatocytes, sinusoids, Disse's space collagen electron microscopy. The wedged hepatic gradient increased with progression disease hypertension was present before histologically detectable cirrhosis had developed. With increasing towards cirrhosis, relationship between individual aggregated features WHVPG diminished lost statistical significance. Hepatocyte histological changes correlated significantly increase WHVPG, both non-alcoholic alcoholic patients. chronic active hepatitis compared patients near-normal liver. No significant decrease sinusoidal found. Multiple rather than any single feature influence development