Towards an unifying perspective of the fundamental properties and structural principles governing the immune system
作者： Paolo Tieri , Claudio Franceschi , Gastone C. Castellani
DOI:
关键词:
摘要: In the study of basic properties observed in immune system and, a broader view, biological systems, several concepts have already been mathematically formulated or treated an analytical perspective, such as degeneracy, robustness, noise, and bow tie architecture. These properties, among others, seem to rule many aspects functioning, share themselvesseveral characteristics, intersecting each other, often becoming one indivisible part other. According Kitano, systems biology needs solid theoretical methodological foundation principles able lead towards unified perspective. An effort unifying formalization analysis these can be now timely attempted.
harvard.edu
arxiv.org参考文章(19)
Paolo Tieri, Gastone C. Castellani, Daniel Remondini, Silvana Valensin, Jonathan Loroni, Stefano Salvioli, Claudio Franceschi, Capturing Degeneracy in the Immune System In Silico Immunology. pp. 109- 118 ,(2007) , 10.1007/978-0-387-39241-7_7
Herman N. Eisen, SPECIFICITY AND DEGENERACY IN ANTIGEN RECOGNITION: Yin and Yang in the Immune System Annual Review of Immunology. ,vol. 19, pp. 1- 21 ,(2001) , 10.1146/ANNUREV.IMMUNOL.19.1.1
Yoram Louzoun, The evolution of mathematical immunology Immunological Reviews. ,vol. 216, pp. 9- 20 ,(2007) , 10.1111/J.1600-065X.2006.00495.X
Hiroaki Kitano, Towards a theory of biological robustness. Molecular Systems Biology. ,vol. 3, pp. 137- 137 ,(2007) , 10.1038/MSB4100179
John R. S. Newman, Sina Ghaemmaghami, Jan Ihmels, David K. Breslow, Matthew Noble, Joseph L. DeRisi, Jonathan S. Weissman, Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise Nature. ,vol. 441, pp. 840- 846 ,(2006) , 10.1038/NATURE04785
Ertugrul M. Ozbudak, Mukund Thattai, Iren Kurtser, Alan D. Grossman, Alexander van Oudenaarden, Regulation of noise in the expression of a single gene Nature Genetics. ,vol. 31, pp. 69- 73 ,(2002) , 10.1038/NG869
Mukund Thattai, Alexander van Oudenaarden, Attenuation of Noise in Ultrasensitive Signaling Cascades Biophysical Journal. ,vol. 82, pp. 2943- 2950 ,(2002) , 10.1016/S0006-3495(02)75635-X
M. Thattai, A. van Oudenaarden, Intrinsic noise in gene regulatory networks Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 8614- 8619 ,(2001) , 10.1073/PNAS.151588598
Marie E Csete, John C Doyle, Reverse engineering of biological complexity. Science. ,vol. 295, pp. 1664- 1669 ,(2002) , 10.1126/SCIENCE.1069981
G. Tononi, O. Sporns, G. M. Edelman, Measures of degeneracy and redundancy in biological networks Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3257- 3262 ,(1999) , 10.1073/PNAS.96.6.3257