Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population

摘要: Patients with chronic heart failure (CHF) express enhanced catabolic metabolism finally resulting in overall weight loss, whereas adipokines might play a crucial role signaling among tissues. The aim of this study was to investigate the possible associations defined variability leptin (dbSNP ID rs7799039), proopiomelanocortin rs3754860 and dbSNP rs1009388), receptor gene rs1137101) CHF evaluate their potential as susceptibility genes. case-control comprised total 372 patients Caucasian origin (New York Heart Association [NYHA] functional classes II-IV, ejection fraction (EF) <40%) 407 healthy controls. They were genotyped for (LEP) -2548 G/A, (LEPR) Gln223Arg, (POMC) RsaI (5'-untranslated region) C1032G variants (intron 1) using PCR-based methodology. No differences genotype well allele frequencies observed between We constructed POMC RsaI/C1032G haplotypes, having found no significant association body mass index (BMI), left ventricle (LVEF), hypertrophy (LVH) diabetes mellitus (DM). Multivariate regression analyses revealed an approximately 2-fold risk NYHA class IV associated LEPR Gln223Arg (P = 0.0000001, odds ratio [OR] 2.10, 95% confidence interval [CI] 1.56-2.84); it also displayed independent prediction LVEF cases all etiologies 0.002, OR 4.05, CI 1.36-10.06). In subanalyses according etiology showed IHD 0.0001, 2.50, 1.69-3.82) both IV(P 0.007, 2.04, 1.20-3.84) 0.004, 11.87, 2.08-55.6) DCMP patients. polymorphic genes encoding is unclear. Based on our findings, polymorphism could be considered disease modulating factor ischemic or dilated cardiomyopathy