Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure

摘要: Heart failure (HF) is characterized as a limitation to cardiac output that prevents the heart from supplying tissues with adequate oxygen and predisposes individuals pulmonary edema. Impaired function secondary either decreased contractility reducing ejection (systolic failure), diminished ventricular compliance preventing filling (diastolic or both. To study HF etiology, many different techniques have been developed elicit this condition in experimental animals, varying degrees of success. Among rats, surgically induced models are most prevalent, but they bear several shortcomings, including high mortality rates limited recapitulation pathophysiology, progression human HF. Alternatively, number non-invasive induction methods avoid these pitfalls, their merits technical simplicity, reliability, survivability, comparability pathophysiologic pathogenic characteristics reviewed herein. In particular, review focuses on primary mechanisms common genetic strains (spontaneously hypertensive spontaneously pharmacological toxic cardiomyopathy (doxorubicin isoproterenol), dietary salt models, all which shown induce left rat. Additional may potentially enable development new also discussed.