Cholinergic Mechanisms in the Cerebral Cortex Beyond Synaptic Transmission

摘要: Functional overviews of cholinergic mechanisms in the cerebral cortex have traditionally focused on release acetylcholine with modulator and transmitter effects. Recently, however, data emerged that extend role innervations to a range housekeeping metabolic functions. These include regulation amyloid precursor protein (APP) processing production β (Aβ) other APP fragments control phosphorylation microtubule-associated (MAP) tau. Evidence has been also presented for receptor-ligand like interactions receptors soluble Aβ peptide MAP tau, signaling Moreover, high-affinity binding neurotrophin receptor p75 (p75NTR) enriched basalo-cortical projections implicated clearance nucleation plaques. Here, we critically evaluate these unorthodox discuss their neuronal physiology biology Alzheimer's disease.