Structural Maintenance of Chromosomes 4 is a Predictor of Survival and a Novel Therapeutic Target in Colorectal Cancer
作者： Xiao-Dong Feng , Qi Song , Chuan-Wei Li , Jian Chen , Hua-Mei Tang
DOI: 10.7314/APJCP.2014.15.21.9459
关键词:
摘要: Background: Structural maintenance of chromosomes 4 (SMC-4) is a chromosomal ATPase which plays an important role in regulate chromosome assembly and segregation. However, the SMC-4 incidence malignancies, especially colorectal cancer still poorly understood. Materials Methods: We here used quantitative PCR Western blot analysis to examine mRNA protein levels primary paired normal colonic mucosa. clinicopathological significance was assessed by immunohistochemical staining tissue microarray (TMA) 118 cases were with noncancerous tissue. The biological function knockdown measured CCK8 plate colony formation assays. Fluorescence detection has been detect cell cycling apoptosis. Results: expression significantly higher associated T stage, N AJCC stage differentiation. Knockdown suppressed proliferation cells degraded its malignant degree. Conclusions: Our clinical experimental data suggest that may contribute progression carcinogenesis. study provides new therapeutic target for treatment.
koreascience.or.kr参考文章(26)
Susan H Harvey, Michael JE Krien, Matthew J O'Connell, Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases Genome Biology. ,vol. 3, pp. 1- 5 ,(2002) , 10.1186/GB-2002-3-2-REVIEWS3003
Gholamreza Bidkhori, Zahra Narimani, Saman Hosseini Ashtiani, Ali Moeini, Abbas Nowzari-Dalini, Ali Masoudi-Nejad, Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma PLoS ONE. ,vol. 8, pp. e67552- ,(2013) , 10.1371/JOURNAL.PONE.0067552
HOMARE KAWACHI, KEISUKE SUGAHARA, YASUTAKA NAKAMURA, AKIRA KATAKURA, KIYOSHI MINAGUCHI, TAKAHIKO SHIBAHARA, Deletion polymorphism at chromosome 3q26.1 and oral squamous cell carcinoma International Journal of Oncology. ,vol. 42, pp. 384- 390 ,(2013) , 10.3892/IJO.2012.1749
D-W Yan, D-W Li, Y-X Yang, J Xia, X-L Wang, C-Z Zhou, J-W Fan, Y-G Wen, H-C Sun, Q Wang, G-Q Qiu, H-M Tang, Z-H Peng, Ubiquitin D is correlated with colon cancer progression and predicts recurrence for stage II-III disease after curative surgery. British Journal of Cancer. ,vol. 103, pp. 961- 969 ,(2010) , 10.1038/SJ.BJC.6605870
Lei Zhai, Hongzhen Wang, Wen Tang, Wenguang Liu, Shui Hao, Xianlu Zeng, Disturbance in function and expression of condensin affects chromosome compaction in HeLa cells. Cell Biology International. ,vol. 35, pp. 735- 740 ,(2011) , 10.1042/CBI20100646
Alex Chang, Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC Lung Cancer. ,vol. 71, pp. 3- 10 ,(2011) , 10.1016/J.LUNGCAN.2010.08.022
BO ZHOU, TAO YUAN, MENGGANG LIU, HONGMING LIU, JUN XIE, YANBIN SHEN, PING CHEN, Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer. Oncology Reports. ,vol. 28, pp. 1263- 1268 ,(2012) , 10.3892/OR.2012.1929
Mariola Kulawiec, Alfiya F. Safina, Mohamed M. Desouki, Ivan Still, Sei-Ichi Matsui, Andrei Bakin, Keshav K Singh, Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion Cancer Biology & Therapy. ,vol. 7, pp. 1732- 1743 ,(2008) , 10.4161/CBT.7.11.6729
Satoshi Takahashi, Noemi Fusaki, Shigeki Ohta, Yoshihiro Iwahori, Yukihiko Iizuka, Kohei Inagawa, Yutaka Kawakami, Kazunari Yoshida, Masahiro Toda, Downregulation of KIF23 suppresses glioma proliferation. Journal of Neuro-oncology. ,vol. 106, pp. 519- 529 ,(2012) , 10.1007/S11060-011-0706-2
Kirsten A Hagstrom, Victor F Holmes, Nicholas R Cozzarelli, Barbara J Meyer, C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis Genes & Development. ,vol. 16, pp. 729- 742 ,(2002) , 10.1101/GAD.968302