The mechanisms of cytotoxicity of urethane dimethacrylate to Chinese hamster ovary cells
作者： Hsiao-Hua Chang , Mei-Chi Chang , Li-Deh Lin , Jang-Jaer Lee , Tong-Mei Wang
DOI: 10.1016/J.BIOMATERIALS.2010.05.059
关键词:
摘要: Abstract Monomers released from resin-containing products may cause various adverse effects. Urethane dimethacrylate (UDMA) is a principal resin monomer and also major component dental materials. Thus the toxic effects mechanisms should be elucidated for improving of its safety use. Here we investigated UDMA on growth, cell cycle progression, reactive oxygen species (ROS) production glutathione (GSH) alteration in CHO-K1 cells, preventive by antioxidants (NAC catalase) were evaluated. elicited growth inhibition (>0.025 m m ) cells clearly dose-dependent manner. Cell perturbation ROS overproduction observed. A 0.1 m UDMA-induced S-phase arrest accumulation. apoptosis necrosis became significant when concentration was 0.25 m . GSH depletion occurred at treated with UDMA, highly cytotoxic which point myriad under or necrosis. can crucial death cells. Furthermore NAC (0.5–10 m catalase (250–1000 U/ml) obviously attenuated toxicity reducing generation disturbance, dose-related. These results suggest that associated production, depletion, disturbance apoptosis/necrosis.
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