Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors

作者: Kshitij Chhabilbhai Thakkar , Steven Joseph Berthel , Adrian Wai-Hing Cheung , Weiya Yun , Kyungjin Kim

DOI:

关键词:

摘要: The invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the specification claims, which useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, lowering blood glucose concentrations mammals.

参考文章(10)
David F. Mccomsey, Han-Cheng Zhang, Bruce E. Maryanoff, Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists ,(2002)
Rob Hooft van Huijsduijnen, Agnes Bombrun, Dominique Swinnen, Selecting protein tyrosine phosphatases as drug targets Drug Discovery Today. ,vol. 7, pp. 1013- 1019 ,(2002) , 10.1016/S1359-6446(02)02438-8
Nicole Zimmermann, Jesus E. Gonzalez, Yulian Zhang, Lev T. D. Fanning, Andreas P. Termin, Dean M. Wilson, Benzimidazoles useful as modulators of ion channels ,(2004)
Steven A. Roman, Kurt G. R. Sundelin, Stephen A. Salvo, Charles A. Horne, Use of pyrroloquinazolinediamines as pesticides ,(1982)
Arlene Joan Dietrich, Paul Jeffrey Dollings, Jay Edward Wrobel, Naphtho[2,3-b]heteroar-4-yl derivatives ,(1999)
David R. Howes executor by, Kurt W. Ledig, 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines ,(1979)
Maria Niewohner, Dagmar Schauss, Toshiya Moriwaki, Rudy Schreiber, Karl-Heinz Schlemmer, Frank-Gerhard Boss, Martin Hendrix, Franz-Josef Staay, Ulrich Niewohner, Gerhard Konig, Novel substituted imidazotriazinones ,(2002)