Selecting protein tyrosine phosphatases as drug targets

摘要: Protein tyrosine phosphatases (PTPs) have emerged as a new and promising class of signaling targets, since the discovery PTP1B major drug target for diabetes obesity. Blocking individual PTPs results in activation specific phosphorylation events, but matching with such pathways therapeutic indications is complex undertaking. The history shows that its unusual knockout phenotype observations generic antisense inhibitors vivo, not classical molecular biology, triggered rapid development are today being developed clinic.