Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

摘要: Abstract Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), it is becoming clear that the developmental pathways for these are fundamentally different. In particular, endometrioid cancers probably arise by malignant transformation of ectopic endometrial implants called endometriosis not surface epithelium. The PTEN/MMAC gene on chromosome 10q23 a tumor suppressor implicated in pathogenesis wide variety malignancies, but to date, somatic mutations PTEN have been identified studies predominantly serous cancers. cancers, very common tumors type rarely found types, we hypothesized similar subtype bias might be occurring cancer. We analyzed 81 tumors, including 34 endometrioid, 29 serous, 10 8 cell loss heterozygosity (LOH) all 9 coding exons . LOH was among (43%) (28%) infrequent other subtypes. Somatic were detected seven (21%) informative cases, mutation accompanied wild-type allele. One mucinous without shown harbor two mutations. this tumor, appearance areas atypical, contained foci differentiation. majority with grade 1 and/or stage 1, suggesting inactivation an early event tumorigenesis. No or tumors. identification frequent indicates plays significant role etiology subtype. absence consistent hypothesis epithelial through distinct pathways.