Molecular Pathology of Ovarian Cancer
作者： Kruti P. Maniar , Ie-Ming Shih , Robert J. Kurman
DOI: 10.1007/978-1-4614-4900-3_7
关键词: Cancer research 、 Molecular pathology 、 Serous fluid 、 Cancer 、 Wnt signaling pathway 、 Internal medicine 、 KRAS 、 Lynch syndrome 、 PTEN 、 Oncology 、 Ovarian cancer 、 Medicine
摘要: Ovarian cancer is associated with a high morbidity and mortality, the leading cause of gynecologic cancer-related death in US. In recent years, molecular pathophysiology ovarian tumors has been better elucidated, allowing for distinction two tumor types: more indolent type I (encompassing endometrioid, clear cell, low-grade serous, mucinous carcinomas) highly aggressive II high-grade serous carcinomas malignant mixed mullerian tumors). Type are related to abnormalities MAPK signaling pathway (KRAS BRAF mutations), PI3K/Akt2/PTEN pathway, Wnt/beta-catenin as well mutations other genes such ARID1a, PPP2R1A, HNF1-beta. tumors, contrast, characterized by p53, inactivation BRCA1/2 Notch3, Rsf-1, NAC1. this chapter, we discuss characteristics frequency these abnormalities, an emphasis on their implications diagnosis treatment.
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