Critical evaluation of p53 as a prognostic marker in ovarian cancer.

摘要: The tumour suppressor gene encoding p53 has been shown from experimental studies to have a crucial role in how cells respond DNA damage. important functions apoptosis, cell-cycle arrest and repair, largely mediated by its activity on transcription. However, despite this wealth of vitro data, tumours damage induced chemotherapeutic drugs remains controversial. In review, we highlight some the problems surrounding design analysis as prognostic marker clinical outcome, using ovarian cancer an example. We aim build knowledge published literature identify criteria for that should give more definitive estimate drug resistance. A search three public databases keywords combined with Boolean operators identified 64 publications investigating relationship outcome following chemotherapy cancer. Although 43% 215 analyses papers reported significant correlation between status endpoint relevant chemoresistance, only six fulfil minimum none these finds statistically chemotherapy-resistance endpoints. results suggest complex mutation mechanism resistance than is suggested studies.