Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study.
作者： Michael J. Birrer , Kathleen M. Darcy , Larry E. Morrison , Benita Henderson , Leia M. Smith
DOI:
关键词: Ovary 、 Cancer research 、 Gynecologic oncology 、 Cyclin E 、 Cell cycle 、 Immunohistochemistry 、 Fluorescence in situ hybridization 、 Survival rate 、 Endocrinology 、 Ovarian cancer 、 Internal medicine 、 Biology
摘要: Cyclin E is a key regulator of the G(1)-S transition. Abnormalities in cyclin expression have been related to survival variety cancers. This study evaluated prognostic relevance human ovarian cancer. Immunohistochemical was 139 advanced, suboptimally debulked epithelial cancer specimens from patients treated on Gynecologic Oncology Group protocol 111. High protein (> or =40% positive tumor cells) seen 62 (45%) patients. Expression not associated with age, race, stage, grade, cell type, amount residual disease. verses low shorter median (29 +/- 2 versus 35 3 months) and worse overall (P < 0.05). Univariate multivariate regression analyses revealed that high relative 40-50% increase risk death (hazard rate, P = Fluorescence situ hybridization used subset 20 cases examine gene amplification. Eight 10 exhibited amplification gene, whereas only 1 displayed 0.006). an independent poor factor for advanced cancer, it gene.
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