Substituted quinolines for the treatment of protozoan and retrovirus co-infections

作者: Bruno Figadere , Eric Prina , Mohamed Fakhfakh , Alain Fournet , Reynald Hocquemiller

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摘要: The invention relates to the use of quinolines having general formula (I), wherein R 1 denotes H; alkyl C -C 15 ; alkenyl or alkynyl 2 —CHO; heteroaryl; 7 comprising at least one substituent selected from among O, halogen, —OH, —CHO, —COOH, aryloxycarbonyl, alkyloxycarbonyl 8 , alkenyloxycarbonyl 3 9 nitrile, aryl, heteroaryl, arylsulphone, alkylsulphone thioalkyl aminoalkyl bearing NH aleoxy phenoxy, cycloakyl 6 heteroaryloxy, trialkylsilyl in position 3, 8, halogen; —OH; —COOH; —NH2; 10 and do not both denote H. is used for preparation a medicine treat protozoan retrovirus co-infections

参考文章(12)
David Mirelman, Meir Wilchek, Compositions against protozoal diseases ,(1988)
Hideyuki Imazaki, Masazumi Fujikawa, Harumoto Kawaguchi, Yoshio Hayase, Organoboron compounds exhibiting anticoccidial activities ,(1999)
Eduardo Austin, Carlos G Ferrayoli, Rubén A Alonso, Roberto A Rossi, SRN1 reactions of aryl halides with carbanions initiated by sodium amalgam in liquid ammonia Tetrahedron. ,vol. 49, pp. 4495- 4502 ,(1993) , 10.1016/S0040-4020(01)81279-5
Mohamed A Fakhfakh, Xavier Franck, Alain Fournet, Reynald Hocquemiller, Bruno Figadère, Expeditious preparation of 2-substituted quinolines Tetrahedron Letters. ,vol. 42, pp. 3847- 3850 ,(2001) , 10.1016/S0040-4039(01)00604-9
A. Fournet, J. C. Gantier, A. Gautheret, L. Leysalles, M. H. Munos, J. Mayrargue, H. Moskowitz, A. Cavé, R. Hocquemiller, The activity of 2-substituted quinoline alkaloids in BALB/c mice infected with Leishmania donovani Journal of Antimicrobial Chemotherapy. ,vol. 33, pp. 537- 544 ,(1994) , 10.1093/JAC/33.3.537
Johan Thevelein, Dijck Patrick Van, Novel target for antiparasitic agents and inhibitors thereof ,(2000)
Carlo Farina, Michel Jean Roger Martin, Guy Marguerite Marie Gerard Nadler, Stefania Gagliardi, Heteroaromatic pentadienoic acid derivatives useful as inhibitors of bone resorption ,(1997)
Kurt Eichenberger, Max Wilhelm, N-(nitro-furfurylidene-methyl-heterocyclyl)-amidines ,(1965)